biodistribution study japan

The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). This means it was an experiment done with an animal model to predict where the vaccine formulation might go when injected into people. (a) Number of cell-based therapeutic product in cell formulation and number of cell-based therapeutic product with or without biodistribution study in (b) cell-suspension CTP and (c) tissue or cell-sheet CTP (refer to Supplementary Table1). Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chdeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quintero-del Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI; Carra SLE Subcommittee. S1A). Thus, the absence of safety pharmacology studies is endorsed by the CHMP, Committee for Medicinal Products for Human Use. We thought the spike protein was a great target antigen; we never knew it was a toxin. Thus it appears that SARS-CoV-2 hijacks mitochondrial machinery for its own benefit, including DMV biogenesis. No evidence of vaccine-related macroscopic or microscopic findings were found in the ovaries in the repeat-dose toxicity studies (Study 38166 and Study 20GR142), were identified in the DART, Developmental and Reproductive Toxicology, study.*, The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as. At first glance, this information seems relatively straightforward. The greatest mean concentration was found remaining in the injection site at each time point in both sexes. In her paper, Worse Than The Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19, published in the International Journal of Vaccine Theory, Practice and Research in collaboration with Dr. Greg Nigh,16 Seneff explains why the unnatural spike protein is so problematic. This false claim originated from: viral social media post. The results in this review will be a useful resource for implementing BD studies. In summary, normally, the spike protein on a virus will collapse on itself and fall into the cell once it attaches to the ACE2 receptor. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). In a separate study, mice received IV injection of an imaging dose of [ 52 Mn]MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations. Content Deleted, Powerful Billionaires Threaten Mercola, The Strange, New Pattern Showing Up After COVID Vaccine, New World Order Yields to the Great Reset, Worse Than The Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19, Princess of Thailand Potential Heiress to the Throne, Grassley: How My Investigation Into Biden Family Financial Dealings Was Sabo taged, Train Derailment Ground Zero Eye Report, New Palestine Train Derailment and Hazardous Materials, Mike Adams Editorial on Destruction of the Nordstream Pipeline, How America Took Out the Nordstream Pipeline, Reporter Seymour Hersh on How America Took Out the Nord Stream Pipeline: Exclusive TV Interview. Youll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L), ideally through sensible sun exposure. So by vaccinating people, we are inadvertently inoculating them with a toxin.. Avoid all vegetable oils and processed foods. Family threatened, his life threatened. Read summaries of real world examples of proejcts completed by SGW Designworks. In the case of covid-19 vaccines, regulators accepted biodistribution data from past studies performed with related, mostly unapproved compounds that use the same platform technology. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. Genetics Genetics (specified analyses) are not evaluated in this study. Because the synthetic mRNA in the vaccine has been programmed to instruct your cells to produce an unnatural, genetically engineered spike protein. High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. Study: Adverse events following COVID-19 virus vaccination in Japanese young population: The first cross-sectional study conducted by a questionnaire survey after the first-time-injection. PROVES the mRNA moves from the injection site to the blood, then circulates spike proteins throughout the body, attacking the ovaries, liver, neurological tissues, other organs. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called the Bio-Distribution Study. The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. Stop using our children as shields in this battle that is an adult battle.. The biodistribution was also studied in rats, using radiolabeled LNP and luciferase modRNA (study 185350. Would you like email updates of new search results? Explanation: When you receive the covid vaccine, it will not impair the function of your ovaries, just as the coronavirus will not. Thrombocytopenia is a commonly-reported side effect of COVID-19 vaccines, as are blood clots, strokes and lethal heart attacks all of which are pointing toward spike proteins causing vascular damage. "Biodistribution" study of mRNA vaccines. I thought this would be an easy blog to write, cut and dry. An official website of the United States government. -, von der Haar K., Lavrentieva A., Stahl F., Scheper T., Blume C. Lost signature: progress and failures in in vivo tracking of implanted stem cells. Consistent data shows the virus is less severe than influenza in children, strengthening the argument of do kids need the vaccine? Voicing his concern, Bridle asserts: Thats not how this is supposed to work; our kids should not be the guinea pigs. The author, Pankaj Prasun, points out that the virus impact on mitochondria helps explain why COVID-19 is so much deadlier for older people, the obese, and those with diabetes, high blood pressure and heart disease. "The results of this leaked Pfizer study tracing the biodistribution of the vaccine mRNA are not surprising, but the implications are terrifying," Stephanie Seneff, a senior research scientist. See this image and copyright information in PMC. Indeed, for many months, weve known that the worst symptoms of severe COVID-19, blood clotting problems in particular, are caused by the spike protein of the virus. But, as you can see below, unlike Bridle, Politifact neglected to go beyond interviewing someone with such a huge stake in the vaccines success. As part of that research, he and a team of international scientists requested a Freedom of Information Act (FOIA) access to Pfizers biodistribution study from the Japanese regulatory agency. . The first section is labeled: SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of pharmacokinetic study https://www.pmda.go.jp/files/000205400.pdf, Basu J., Assaf B.T., Bertram T.A., Rao M. Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms. It is true that some of experiments looked at the distribution of lipid nanoparticles containing an mRNA coding for Luciferase, a protein that exhibits bioluminescence allowing for visualization where the mRNA ended up. Its very disconcerting. 2009 Aug;(144):3-79. Playing Hardball in Government and Politics, Nuclear War At the Abyss of Mass Extermination, Pfizer Bio-Distribution Study Submitted to the Japanese Government, Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizers biodistribution study from the Japanese regulatory agency. Perhaps the attached study will be helpful to her. 2012;2(4):335345. Bridle explains the study absolutely refutes the premise that the COVID-19 vaccine stays in the shoulder muscle, asserting: The short answeris absolutely not. The EIN for the organization is 59-1630423. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. Assuming that the spike protein would not enter into the circulatory system was a grave mistake, according to Bridle, who calls the Japanese data clear-cut evidence that the vaccine, and the spike protein produced by it, enters your bloodstream and accumulates in vital organs. Why the confusion? Tags:Japan Pfizer spike proteins vaccines. Dysfunctional mitochondria predispose to oxidative stress and loss of cellular function and vitality. Additionally, according to Bridle, an alarming study not yet accepted for publication that initially attempted to verify that antibodies from the vaccine get transferred through breast milk (suggesting some protection for babies), instead inadvertently discovered the mRNA vaccine spike proteins are transferred through the breast milk, thus passing the COVID-19 vaccine vector itself into breastfeeding infants. Time-restricted eating will upregulate autophagy, while sauna therapy, which upregulates heat shock proteins, will help refold misfolded proteins and also tag damaged proteins and target them for removal. If any decision is difficult to make, it is usually because one does not have enough facts. Pingback: 13th June MUST SEE VIDEOS & DOCUMENTS: Based Amy. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Spike protein does not attack anything, it only aims to activate the immune response, it is not the same as coronavirus spike protein and after vaccination, it is created in a dose 100 thousand times lower than in viral infection. Princess Bajrakitiyabha of Thailand collapses, Vaxxed and unvaxxed coming down with same ailments, Sasha Latypova reveals COVID law and contracts, Todd Callender explains the legal framework for pandemics, Sasha Latypova gives a speech in Stockholm, Centers for Disease Control and Prevention, Fact Sheet for Healthcare Providers Administering Vaccine, https://www.fda.gov/media/144413/download, https://uncoverdc.com/wp-content/uploads/2021/05/Bridle.pdf.pagespeed.ce.aKOeaMY9Wh.pdf, https://omny.fm/shows/on-point-with-alex-pierson/new-peer-reviewed-study-on-covid-19-vaccines-sugge, https://www.lifesitenews.com/news/vaccine-researcher-admits-big-mistake-says-spike-protein-is-dangerous-toxin/, https://trialsitenews.com/did-pfizer-fail-to-perform-industry-standard-animal-testing-prior-to-initiation-of-mrna-clinical-trials/, https://www.youtube.com/watch?v=Du2wm5nhTXY, https://www.bitchute.com/video/UfFOTCxRORsp/, https://www.bitchute.com/video/T71ZVNAXi0jW/, https://rumble.com/v15oqc7-dr.-richard-urso-the-explosion-of-cancer-and-latent-disease-from-the-vaccin.html, First case of autopsy in a patient vaccinated against COVID-19, Report: mRNA vaccines is converted to DNA in the liver, Vaccine-Induced Covid-19 Mimicry Syndrome, Brian Gerrish explains the psychological manipulation of the public . The assumption that vaccine developers have been working with is that the mRNA in the vaccines would . When blood clots completely block a blood vessel, you end up with a stroke or a heart attack. Information on the biodistribution (BD) of cell therapy products (CTPs) is essential for prediction and assessment of their efficacy and toxicity profiles in non-clinical and clinical studies. This is important to understand. "We made a big mistake," Bridle says. So the Japanese medicines regulator had required Pfizer to do a study where they looked at how the vaccine distributed around the body, in this case of a . Specific alterations make it far more toxic than that found on the virus itself. Any objections based on the experimental status of this vaccine are now moot. This is about as diabolical as it gets. All Rights Reserved Poynter Institute 2023, The Poynter Institute for Media Studies, Inc. is a non-profit 501(c)3. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. A study with the same platform vector ChAdOx -1 (hepatitis B virus) and two studies with a similar viral vector (ChAd63) were also carried out and the results are summarised qualitatively in the EPAR. Bridle details further, explaining: The assumption until now has been that these vaccines behave like all of our traditional vaccines; that they dont go anywhere, they stay in our shoulder. The petition and its supporting documents can be downloaded from the FDA website here: https://www.regulations.gov/docket/FDA-2021-P-0521/document, However, information regarding biodistribution of the Pfizer vaccine in animal studies was referenced by the European Medicine Agencys (EMA) review of Pfizers mRNA vaccine data sent to them by Pfizer. It was a pre-clinical biodistribution study. Furthermore, in key studies designed to test whether the vaccine remains near the injection site or travels throughout the body, Pfizer did not even use the commercial vaccine (BNT162b2) but instead relied on a surrogate mRNA producing the luciferase protein. It also was featured in a fact check by The Poynter Institutes Politifact,2 which pronounced Bridles findings as false after interviewing Dr. Drew Weissman,3 a UPenn scientist who is credited with helping to create the technology that enables the COVID mRNA vaccines to work. This document . National Library of Medicine That, of course, is the type that's produced in a living cell by reading off a given stretch of DNA and assembling the matching RNA, after which it goes off on its own to be fed into a ribosome which will assemble proteins based on its code, reading off by three "codon" letters at a time. Your body for some reason starts to attack the lining of your blood vessels, thereby causing damage and inflammation The why can differ from one case to another, but in all cases, your immune system identifies something foreign in the lining of the blood vessel, causing it to attack. government site. The spike protein gets into the blood, circulates through the blood in individuals over several days post-vaccination. This is in contrast to current thinking the mRNA vaccine is quickly broken down at its site of injection in the arm implying no distribution to other organs. Whats more, because the RNA code has been enriched with extra guanines (Gs) and cytosines (Cs), and configured as if its a human messenger RNA molecule ready to make protein by adding a polyA tail, the spike proteins RNA sequence in the vaccine looks as if it is part bacteria,17 part human18 and part viral at the same time. DNA Extraction Method Affects the Detection of a Fungal Pathogen in Formalin-Fixed Specimens Using qPCR. The signal decreased slowly during the first 72 hours and after 6 and 9 days the signals were further weakened to approximately levels of 18 and 7 times the signals obtained from animals injected with buffer control. Pfizers data, however, show the mRNA and subsequent spike protein are widely distributed in the body within hours, This is a serious problem, as the spike protein is a toxin shown to cause cardiovascular and neurological damage. I wanted links for my wife who is Japanese and could not understand my resistance to them. Now, we have clear-cut evidence that the vaccines that make the cells in our deltoid muscles manufacture this protein, [we now know] the vaccine itself plus the protein gets into blood circulation. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. Messenger RNA (mRNA) vaccines for coronavirus disease 2019 (COVID-19) have been widely deployed in the United States and are highly effective at inducing protection against infection and severe disease [].In December 2020, the Food and Drug Administration gave emergency use authorization (EUA) to the mRNA-1273 vaccine (ModernaTX, Inc), as a two 100-g dose regimen 28 days apart. Parkinsons disease is a prion disease that has been traced back to prions originating in the spleen, that then travel up to the brain via the vagus nerve. Scientists discovered the SARS-CoV-2 spike protein circulating in the blood of eleven of the thirteen healthcare workers. Not so. We never knew the spike protein itself was a toxin and was a pathogenic protein. Manipulation of mitochondria by virus may lead to mitochondrial dysfunction and increased oxidative stress ultimately leading to loss of mitochondrial integrity and cell death , Mitochondrial fission enables removal of the damaged portion of a mitochondrion to be cleared by mitophagy (a special form of autophagy). Human organ radiation dosimetry is shown in Table 2. Hello do you have an updated link to the old Japanese Pfizer study? (a) DNA extraction, (b) PCR detection, (c) units, and (d) primer and probe sequences (refer to Supplementary Table3). The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. After spending 20 hours of research, I found there are. Canadian virologist Byram Bridle, believes anti-Covid vaccines are directly responsible for cardiovascular injury and death as proposed by the first-of-its-kind "biodistribution" study from Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer/BioNTech cause the . To combat the toxicity of the spike protein, youll want to optimize autophagy, which may help digest and remove the spike proteins. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018 in comparison among (a) local or systemic administration product, (b) commercialized or product in clinical phases, (c) biodistribution measurement modalities, (d) clinical phases of development, (e) used animal species and (f) measurement modalities and biodistribution study duration (refer to Supplementary Table1). Rightly, Bridle is extremely troubled about the current drive to vaccinate children against COVID-19, recently stating insufficient evidence exists to claim the benefits outweigh the risk of vaccinating the younger population. Why? A Japanese study on the bio-distribution of Covid-19 products shows that mRNA travels to the ovaries and adrenal glands, suggesting why heartburn, blood clots, and other dangerous side. I am giving you the technical version so you can see for yourself the actual data reviewed by EMA. Japanese Biodistribution study that Dr. Byram Bridle warned about showing that lipid-nano particles, the mRNA & thus possible spike bio-accumulated in distant tissue & organs based on rat model; Table Bridle was pilloried by all, the media, his insane putrid University colleagues etc. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. Bridle cites research showing that laboratory animals injected with purified spike protein from SARS-CoV-2 straight into their bloodstream developed cardiovascular problems and brain damage. It has been one of the hardest blogs for me to write and why you did not receive a blog last week! In my interview with Seneff and Mikovits (see earlier hyperlink), they both stressed that the key danger both in COVID-19 and with the vaccines is the spike protein itself. That is, luciferase RNA inclusion LNP was intramuscularly administered to the left and right hind limbs of mice at a dose of 1 g RNA (2 g RNA in total). Since any protein in the blood will concentrate in breast milk, observing that the spike protein gets into circulation is even more disturbing. The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. This does not mean the animal studies were not done. 2018;7(1):7886. It is important that your sauna is hot enough (around 170 degrees Fahrenheit) and does not have high magnetic or electric fields. 2020 Jun 1;18:176-188. doi: 10.1016/j.omtm.2020.05.029. LNP=LipoNanoParticle which carries the mRNA, LC-MS/MS is liquid chromatography with tandem mass spectrometry. Bittorf P, Bergmann T, Merlin S, Olgasi C, Pullig O, Sanzenbacher R, Zierau M, Walles H, Follenzi A, Braspenning J. Mol Ther Methods Clin Dev. It is certainly understandable why the vaccine was rushed into use as an experimental product under emergency use authority, but these new findings suggest that routine quality testing issues were overlooked in the rush to authorize use. In biodistribution study, two groups of SD rats (15 rats/sex/group) were injected intramuscularly with AdC68-19S 2 10 11 vp (twofold the proposed clinical dose of 1 10 11 vp/dose) or vehicle, respectively, on day 1. official website and that any information you provide is encrypted After the protein piece is made, the cell breaks down the instructions and gets rid of them. What is the length of time the vaccine exists in the body after vaccination? In a recent interview1 with Alex Pierson (above), Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., dropped a shocking truth bomb that immediately went viral, despite being censored by Google. Nonetheless, he insists science must be properly performed and then followed carefully before entering into the public rollout of vaccines. Some of the protein will go to the local draining lymph node in order to activate the immune system., Please consider leaving a comment on the FDA petition to revoke the EUA & prevent licensure of the COVID injections. Whats more, TrialSite News reports6 that Pfizer documents submitted to the European Medicines Agency [EMA] reveal the company did not follow industry-standard quality management practices during preclinical toxicology studies as key studies did not meet good laboratory practice (GLP)., Neither reproductive toxicity nor genotoxicity (DNA mutation) studies were performed, both of which are considered critical when developing a new drug or vaccine for human use. The thirteen healthcare workers properly performed and then followed carefully before entering the... 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